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KMID : 0385219990090020054
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Korean Journal of Gerontology
1999 Volume.9 No. 2 p.54 ~ p.61
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High Fat Diet Promotes DHEA-induced Peroxisomal Proliferation in Rat Liver
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Kwak Chung-Shil
Park Sang-Cheol
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Abstract
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We have intended to find whether the dietary fat level and source modulate the activities of peroxisomal enzymes and cytochrome P450 4Al content in 0.2% of DHEA diet 186 rat liver, Sprague-Dawley male rats were fed on semipurified diet containing either 2% (w/w) of corn oil (5 cal % of fat; low level of corn oil diet), 15% (w/w) of corn oil (31 cal % of fat; high level of corn oil diet) or 13% (w/w) of sardine oil plus 2% (w/w) of corn oil (31 cal % of fat; high level of fish oil diet) for 9 weeks. The half induced the hepatomegaly, and high fish oil diet caused a mild hepatomegaly. Liver weight was positively correlated with palmitoyl-coA oxidase aetivity in liver (r = 0.4587, p < 0.05). High fat diet increased significantly palmitoyl-coA oxides activity without increase of catalase activity in DHEA administered rats compared to low fat diet Fish oil diet significantly increased the amount of cytochrome P45O 4Al in liver, and DHEA administration increased it in corn oil diet-fed rats not in fish oil diet-fed rats. In conclusion, the effects of DHEA administration on peroxisomal enzymes and cytochrome P45O 4Al in liver were modulated by dietary fat level or source: high fat diet further activated DHEA-induced peroxisomal enzyme activation and high level of fish oil intake induced cytochrome P45O 4Al more strongly than DHEA.
Therefore, low fat diet could minimize the possible side effects in liver caused by DHEA administration.
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KEYWORD
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Dehydroepiandrosterone, Peroxisomal enzymes, Cytochrome P450 4A1, fish oil diet, Hepatomegaly
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